Cellular Immune Responses to Nine Mycobacterium tuberculosis Vaccine Candidates following Intranasal Vaccination

@inproceedings{Sable2011CellularIR,
  title={Cellular Immune Responses to Nine Mycobacterium tuberculosis Vaccine Candidates following Intranasal Vaccination},
  author={Suraj B. Sable and Mani Cheruvu and Subhadra Nandakumar and Sunita Sharma and Kakali Bandyopadhyay and Kathryn L. Kellar and James E Posey and Bonnie B. Plikaytis and Rama Rao Amara and Thomas M. Shinnick},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND The identification of Mycobacterium tuberculosis vaccines that elicit a protective immune response in the lungs is important for the development of an effective vaccine against tuberculosis. METHODS AND PRINCIPAL FINDINGS In this study, a comparison of intranasal (i.n.) and subcutaneous (s.c.) vaccination with the BCG vaccine demonstrated that a single moderate dose delivered intranasally induced a stronger and sustained M. tuberculosis-specific T-cell response in lung parenchyma… CONTINUE READING
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