Cellular Homeostasis and Aging.

@article{Hartl2016CellularHA,
  title={Cellular Homeostasis and Aging.},
  author={F. Ulrich Hartl},
  journal={Annual review of biochemistry},
  year={2016},
  volume={85},
  pages={1-4}
}
Aging and longevity are controlled by a multiplicity of molecular and cellular signaling events that interface with environmental factors to maintain cellular homeostasis. Modulation of these pathways to extend life span, including insulin-like signaling and the response to dietary restriction, identified the cellular machineries and networks of protein homeostasis (proteostasis) and stress resistance pathways as critical players in the aging process. A decline of proteostasis capacity during… CONTINUE READING
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