Cellular Expression, Trafficking, and Function of Two Isoforms of Human ULBP5/RAET1G

@article{Eagle2009CellularET,
  title={Cellular Expression, Trafficking, and Function of Two Isoforms of Human ULBP5/RAET1G},
  author={Robert A. Eagle and Gillian Flack and Anthony Warford and Jes{\'u}s Mart{\'i}nez-Borra and Insiya Jafferji and James A Traherne and Maki Ohashi and Louise H Boyle and Alexander David Barrow and Sophie Caillat-Zucman and Neil T. Young and John Trowsdale},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={781 - 790}
}
BACKGROUND The activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D contributes to anti-tumour and anti-viral immune responses in vitro and in vivo. The ligands for NKG2D in humans are diverse proteins of the MIC and ULBP/RAET families that are upregulated on the surface of virally infected cells and tumours. Two splicing variants of ULBP5/RAET1G have been cloned previously, but not extensively characterised. METHODOLOGY/PRINCIPAL FINDINGS We… CONTINUE READING

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