888 Citations
Oxygen, homeostasis, and metabolic regulation.
- BiologyAdvances in experimental medicine and biology
- 2000
The polarization illustrated by these two views of living cells extends throughout the metabolic regulation field and has caused the field to progress along two surprisingly independent paths with minimal communication between them and the time may have come when cross talk between the two fields may be useful.
The metabolic implications of intracellular circulation.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1999
These new studies raise a model II hypothesis of intracellular perfusion or convection as a primary means for bringing enzymes and substrates together under variable metabolic conditions with no requirement for large simultaneous changes in substrate concentrations.
The dynamic basis of energy transduction in enzymes.
- Biology, ChemistryBiochimica et biophysica acta
- 1984
The adenylate energy charge in the study of enzymes in vitro.
- Biology, ChemistryMethods in enzymology
- 1979
Genetics of Energetics: Transcriptional Responses in Cardiac Metabolism
- BiologyAnnals of Biomedical Engineering
- 2004
A model of feedback/feedforward between genes and proteins is needed to explain the principle of reestablishing homeostatic control of metabolism as cellular and external environments change.
Some thoughts on the evolutionary basis for the prominent role of ATP and ADP in cellular energy metabolism.
- Biology, ChemistryJournal of theoretical biology
- 1984
Information transfer in metabolic pathways
- Biology
- 2001
Various metabolic models have been studied by computer simulation in an effort to understand why allowing for the reversibility of the reaction catalysed by pyruvate kinase, normally considered as…
Control of respiration and ATP synthesis in mammalian mitochondria and cells.
- BiologyThe Biochemical journal
- 1992
We have seen that there is no simple answer to the question 'what controls respiration?' The answer varies with (a) the size of the system examined (mitochondria, cell or organ), (b) the conditions…
OPPORTUNITIES FOR NEW SYNTHESIS
- Biology
- 1985
It is suggested that a bioenergetic viewpoint, unifying biochemical and ecological perspectives, may be very helpful in evolutionary genetics, and raises some specific questions about the role of mechanistic studies in evolutionary biology.
Reflections on Energy Conversion in Biological and Biomimetic Systems
- Chemistry
- 2011
In principle any form of energy (light, electrical, potential, chemical, kinetic energy, etc.) can be converted into any other, and a large part of biochemistry is concerned with the mechanisms of…