Cellular Energy Metabolism and its Regulation

  title={Cellular Energy Metabolism and its Regulation},
  author={Daniel E. Atkinson},

Oxygen, homeostasis, and metabolic regulation.

The polarization illustrated by these two views of living cells extends throughout the metabolic regulation field and has caused the field to progress along two surprisingly independent paths with minimal communication between them and the time may have come when cross talk between the two fields may be useful.

The metabolic implications of intracellular circulation.

  • P. W. Hochachka
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
These new studies raise a model II hypothesis of intracellular perfusion or convection as a primary means for bringing enzymes and substrates together under variable metabolic conditions with no requirement for large simultaneous changes in substrate concentrations.

The dynamic basis of energy transduction in enzymes.

Genetics of Energetics: Transcriptional Responses in Cardiac Metabolism

A model of feedback/feedforward between genes and proteins is needed to explain the principle of reestablishing homeostatic control of metabolism as cellular and external environments change.

Information transfer in metabolic pathways

Various metabolic models have been studied by computer simulation in an effort to understand why allowing for the reversibility of the reaction catalysed by pyruvate kinase, normally considered as

Control of respiration and ATP synthesis in mammalian mitochondria and cells.

  • G. Brown
  • Biology
    The Biochemical journal
  • 1992
We have seen that there is no simple answer to the question 'what controls respiration?' The answer varies with (a) the size of the system examined (mitochondria, cell or organ), (b) the conditions


It is suggested that a bioenergetic viewpoint, unifying biochemical and ecological perspectives, may be very helpful in evolutionary genetics, and raises some specific questions about the role of mechanistic studies in evolutionary biology.

Reflections on Energy Conversion in Biological and Biomimetic Systems

In principle any form of energy (light, electrical, potential, chemical, kinetic energy, etc.) can be converted into any other, and a large part of biochemistry is concerned with the mechanisms of