Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa

  title={Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa},
  author={Susan Hall and Catherine M. McDermott and Shailendra Anoopkumar-Dukie and Amelia McFarland and Amanda Forbes and Anthony V. Perkins and Andrew K. Davey and Russ Chess-Williams and Milton J Kiefel and Devinder S. Arora and Gary Dean Grant},
Pyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems. It has been shown that a large number of the effects to these systems are via the formation of reactive oxygen species. The limitations of studies are, to date, focused on the localized… CONTINUE READING
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