Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(β-L-Malic Acid)

  title={Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly($\beta$-L-Malic Acid)},
  author={Rameshwar Patil and Jos{\'e} Antonio Portilla-Arias and Hui Ding and Bindu Konda and Arthur Rekechenetskiy and Satoshi Inoue and Keith L. Black and Eggehard Holler and Julia Y. Ljubimova},
  journal={International Journal of Molecular Sciences},
  pages={11681 - 11693}
Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and shows improved delivery, reduced toxicity and higher treatment efficacy when being part of nanoscale delivery systems. However, a major drawback remains its toxicity to healthy tissue and the development of multi-drug resistance during prolonged treatment. This is why in our work we aimed to improve DOX delivery and reduce the toxicity by chemical conjugation with a new nanoplatform based on polymalic acid. For… 

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