Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein.

@article{Chen2014CellularDR,
  title={Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein.},
  author={Guifang Chen and Chien-Hung Liu and Ligang Zhou and Robert Krug},
  journal={Cell host & microbe},
  year={2014},
  volume={15 4},
  pages={484-93}
}
Influenza A virus RNA synthesis is catalyzed by the viral polymerase comprised of the PA, PB1, and PB2 proteins. We show that the host DDX21 RNA helicase restricts influenza A virus by binding PB1 and inhibiting polymerase assembly, resulting in reduced viral RNA and protein synthesis. Later during infection, the viral NS1 protein overcomes this restriction by binding to DDX21 and displacing PB1. DDX21 binds to a region of the NS1 N-terminal domain that also participates in other critical… CONTINUE READING

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The NS1 protein: A master regulator of host and viral functions

  • R. M. Krug, A. Garcia-Sastre
  • Textbook of Influenza, 2nd edition, R.G.Webster…
  • 2013
Highly Influential
5 Excerpts

Orthomyxoviruses

  • P. F. Wright, G. Neumann, Y. Kawaoka
  • Fields Virology, 6th edition, D.M. Knipe and P.M…
  • 2013
1 Excerpt

The virus genome and its replication

  • R. M. Krug, E. Fodor
  • Textbook of Influenza, 2nd edition, R.G. Webster…
  • 2013
3 Excerpts

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