Cellular Contraction and Polarization Drive Collective Cellular Motion.

  title={Cellular Contraction and Polarization Drive Collective Cellular Motion.},
  author={Jacob K Notbohm and Shiladitya Banerjee and Kazage J C Utuje and Bomi Gweon and Hwanseok Jang and Yongdoo Park and Jennifer H. Shin and James P. Butler and Jeffrey J. Fredberg and M. Cristina Marchetti},
  journal={Biophysical journal},
  volume={110 12},
Coordinated motions of close-packed multicellular systems typically generate cooperative packs, swirls, and clusters. These cooperative motions are driven by active cellular forces, but the physical nature of these forces and how they generate collective cellular motion remain poorly understood. Here, we study forces and motions in a confined epithelial monolayer and make two experimental observations: 1) the direction of local cellular motion deviates systematically from the direction of the… CONTINUE READING
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