Cellular Changes in Blood Indicate Severe Respiratory Disease during Influenza Infections in Mice

@inproceedings{Dengler2014CellularCI,
  title={Cellular Changes in Blood Indicate Severe Respiratory Disease during Influenza Infections in Mice},
  author={Leonie Dengler and Nora K{\"u}hn and Dai-Lun Shin and Bastian Hatesuer and Klaus Schughart and Esther Wilk},
  booktitle={PloS one},
  year={2014}
}
Influenza A infection is a serious threat to human and animal health. Many of the biological mechanisms of the host-pathogen-interactions are still not well understood and reliable biomarkers indicating the course of the disease are missing. The mouse is a valuable model system enabling us to study the local inflammatory host response and the influence on blood parameters under controlled circumstances. Here, we compared the lung and peripheral changes after PR8 (H1N1) influenza A virus… CONTINUE READING
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