Cellular Biology Regulation of Cardiomyocyte Polyploidy and Multinucleation by CyclinG1


Rationale: Polyploidy and multinucleation are characteristic features of mammalian cardiomyocytes, which develop shortly after birth when most differentiated cardiomyocytes become acytokinetic. Cardiac overload and hypertrophy further increase the degree of polyploidy of cardiomyocytes, suggesting a role in cell type–specific responses to physiological and… (More)


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