Cellular Aspects of Transvascular Exchange: A 40‐Year Perspective

@article{Renkin1994CellularAO,
  title={Cellular Aspects of Transvascular Exchange: A 40‐Year Perspective},
  author={Eugene M. Renkin},
  journal={Microcirculation},
  year={1994},
  volume={1}
}
Study of the microcirculation began with microscopic anatomy in the 17th century, but it was not until the mid‐19th century that the concept of microcirculatory exchange was developed, in association with the great expansion in knowledge of physical chemistry and cell biology. In the first half of the 20th century, the roles of diffusion and osmosis (ultrafiltration) were put on a quantitative foundation and the physiological basis for regulation of the microcirculation was established. During… 
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17 Citations
Background Citations
6

17 Citations

Microcirculatory Exchange Function
EVIDENCE OF TRANSCELLULAR ALBUMIN TRANSPORT after HEMORRHAGIC SHOCK
TLDR
The results demonstrated a marked increase in albumin leak after hemorrhagic shock that was significantly attenuated with two different inhibitors of transcellular transport, N-ethylmaleimide and methyl-β-cyclodextrin, suggesting that caveolae transport plays a significant role in microvascular permeability after hemorrhage.
Evidence of transcellular permeability pathway in microvessels.
TLDR
The results indicate that the gp60-dependent pathway is important in regulating endothelial permeability in situ via a transcellular mechanism and suggests that plasmalemmal membrane traffic across the skeletal muscle microvessel barrier is a constitutively active process.
Advection and Diffusion of Substances in Biological Tissues With Complex Vascular Networks
TLDR
A more realistic multicapillary network model conforming statistically to morphometric data is constructed that serves as a reference standard against which to evaluate computationally simpler, less physically realistic models.
Regulation of Endothelial Barrier Function
TLDR
A major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood–tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues.
Near-wall micro-PIV reveals a hydrodynamically relevant endothelial surface layer in venules in vivo.
TLDR
The findings confirm the presence of a hydrodynamically effective endothelial surface layer, and emphasize the need to revise previous concepts of leukocyte adhesion, stress transmission to vascular endothelium, permeability, and mechanotransduction mechanisms.
Capillary endothelial surface layer selectively reduces plasma solute distribution volume.
  • H. Vink, B. Duling
  • Biology
    American journal of physiology. Heart and circulatory physiology
  • 2000
TLDR
It is demonstrated that for anionic molecules size and charge have a profound effect on the penetration rate into the glycocalyx, including molecular size, charge, and structure.
Near-Wall μ-PIV Reveals a Hydrodynamically Relevant Endothelial Surface Layer in Venules In Vivo
Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties
  • L. Gallelli
  • Biology, Medicine
    Drug design, development and therapy
  • 2019
TLDR
The ability of escin to prevent hypoxia-induced disruption to the normal expression and distribution of platelet endothelial cell-adhesion molecule-1 may help explain its protective effect on blood vessel permeability.
CPMG relaxation rate dispersion in dipole fields around capillaries.
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References

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TLDR
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TLDR
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TLDR
The basement membrane and a fibrous matrix secreted by endothelial cells into the gaps may offer resistance to exchange in the high permeability state.
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TLDR
Preliminary experiments show that the permeability of frog capillaries can be varied by varying concentrations of Mg2+ (rather than Ca2+) in the presence of the ionophore A23187 and suggest an interesting line of investigation.
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