Cellular Aspects of Transvascular Exchange: A 40‐Year Perspective

@article{Renkin1994CellularAO,
  title={Cellular Aspects of Transvascular Exchange: A 40‐Year Perspective},
  author={Eugene M. Renkin},
  journal={Microcirculation},
  year={1994},
  volume={1}
}
Study of the microcirculation began with microscopic anatomy in the 17th century, but it was not until the mid‐19th century that the concept of microcirculatory exchange was developed, in association with the great expansion in knowledge of physical chemistry and cell biology. In the first half of the 20th century, the roles of diffusion and osmosis (ultrafiltration) were put on a quantitative foundation and the physiological basis for regulation of the microcirculation was established. During… 
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References

SHOWING 1-10 OF 58 REFERENCES
Flow and Diffusion Through Biological Membranes
TLDR
This chapter is concerned largely with the application of van’t Hoff’s theorem to fluid movement and effective osmotic pressures across organized biological membranes such as capillary endothelium, glomerular membranes, or leaky epithelia.
The Eugene M. Landis Award Lecture 1993 Regulation of Water and Solute Exchange in Microvessel Endothelium: Studies in Single Perfused Capillaries
TLDR
The methods that Dr. Landis developed and used to investigate exchange of substances across the walls of single capillaries have been the basis for much of the research in my laboratory.
Effects of alterations in endothelial cell volume on transendothelial albumin permeability
TLDR
Results indicate that the pulmonary artery endothelial cells in culture alter their cell volume when exposed to variations in the osmotic environment, and also show RVD in response to hypotonic conditions but no RVI within 40 minutes after exposure to hypertonic conditions.
The Malpighi lecture. Vascular permeability--the consequence of Malpighi's hypothesis.
  • C. Michel
  • Biology
    International journal of microcirculation, clinical and experimental
  • 1985
TLDR
Preliminary experiments show that the permeability of frog capillaries can be varied by varying concentrations of Mg2+ (rather than Ca2+) in the presence of the ionophore A23187 and suggest an interesting line of investigation.
Graded modulation of frog microvessel permeability to albumin using ionophore A23187.
TLDR
The basement membrane and a fibrous matrix secreted by endothelial cells into the gaps may offer resistance to exchange in the high permeability state.
The Malpighi lecture. Vascular permeability--the consequence of Malpighi's hypothesis.
TLDR
Preliminary experiments show that the permeability of frog capillaries can be varied by varying concentrations of Mg2+ (rather than Ca2+) in the presence of the ionophore A23187 and suggest an interesting line of investigation.
The role of vesicles in the transport of ferritin through frog endothelium.
TLDR
It is suggested that the early constant labelling of cytoplasmic and abluminal vesicles is consistent with the existence of vesicular channels, and albumin may affect vesicle transport by its interaction with the endothelial glycocalyx.
Effective osmotic pressure of the plasma proteins and other quantities associated with the capillary circulation in the hindlimbs of cats and dogs.
TLDR
This behavior represents a special case of the Starling theory in which tissue pressure opposing filtration is negligible and the capillary membranes are almost completely impermeable to the plasma proteins; it implies that the protein concentration in tissue fluid immediately outside the capillaries is too low to play a significant role in determining the osmotic balance.
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