Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors.

Abstract

The protein arginine deiminases (PADs) catalyze the post-translational deimination of arginine side chains. Multiple PAD isozymes have been characterized, and abnormal PAD activity has been associated with several human disease states. PAD3 has been characterized as a modulator of cell growth via apoptosis inducing factor and has been implicated in the… (More)
DOI: 10.1021/acsmedchemlett.6b00215

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