Cellular / Molecular Protein – Protein Coupling / Uncoupling Enables Dopamine D 2 Receptor Regulation of AMPA Receptor-Mediated Excitotoxicity

@inproceedings{Zou2005CellularM,
  title={Cellular / Molecular Protein – Protein Coupling / Uncoupling Enables Dopamine D 2 Receptor Regulation of AMPA Receptor-Mediated Excitotoxicity},
  author={Shengwei Zou and Lei Li and Lin Pei and Brian Vukusic and Hubert H. M. Van Tol and Frank J S Lee and Qi Wan and Fang Liu},
  year={2005}
}
There is considerable evidence that dopamine D2 receptors can modulate AMPA receptor-mediated neurotoxicity. However, the molecular mechanism underlying this process remains essentially unclear. Here we report that D2 receptors inhibit AMPA-mediated neurotoxicity through two pathways: the activation of phosphoinositide-3 kinase (PI-3K) and downregulation of AMPA receptor plasma membrane expression, both involving a series of protein–protein coupling/uncoupling events. Agonist stimulation of D2… CONTINUE READING
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