Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration.

@article{Sekiya2015CellsTO,
  title={Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration.},
  author={Tetsuji Sekiya and Matthew C. Holley and Kento Hashido and Kazuya Ono and Koichiro Shimomura and Rie T Horie and Kiyomi Hamaguchi and Atsuhiro Yoshida and Tatsunori Sakamoto and Juichi Ito},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 26},
  pages={E3431-40}
}
Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders, including spinal cord injury, Parkinson's disease, and amyotrophic lateral sclerosis. Indeed, patients have high hopes for a cell-based therapy. However, there are numerous practical challenges for clinical translation. One major problem is that only very low numbers of donor cells survive and achieve functional integration into the host. Glial scar tissue in chronic… CONTINUE READING

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Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders , including spinal cord injury , Parkinson 's disease , and amyotrophic lateral sclerosis .
Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders , including spinal cord injury , Parkinson 's disease , and amyotrophic lateral sclerosis .
Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders , including spinal cord injury , Parkinson 's disease , and amyotrophic lateral sclerosis .
Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders , including spinal cord injury , Parkinson 's disease , and amyotrophic lateral sclerosis .
However , when donor cells are placed on the surface of a ChABC - treated gliotic auditory nerve , they autonomously migrate into it and recapitulate glia- and neuron - guided cell migration modes to repair the auditory pathway and recover auditory function .
However , when donor cells are placed on the surface of a ChABC - treated gliotic auditory nerve , they autonomously migrate into it and recapitulate glia- and neuron - guided cell migration modes to repair the auditory pathway and recover auditory function .
However , when donor cells are placed on the surface of a ChABC - treated gliotic auditory nerve , they autonomously migrate into it and recapitulate glia- and neuron - guided cell migration modes to repair the auditory pathway and recover auditory function .
However , when donor cells are placed on the surface of a ChABC - treated gliotic auditory nerve , they autonomously migrate into it and recapitulate glia- and neuron - guided cell migration modes to repair the auditory pathway and recover auditory function .
Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders , including spinal cord injury , Parkinson 's disease , and amyotrophic lateral sclerosis .
Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders , including spinal cord injury , Parkinson 's disease , and amyotrophic lateral sclerosis .
Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders , including spinal cord injury , Parkinson 's disease , and amyotrophic lateral sclerosis .
Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders , including spinal cord injury , Parkinson 's disease , and amyotrophic lateral sclerosis .
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