Cells test substrate rigidity by local contractions on submicrometer pillars.

  title={Cells test substrate rigidity by local contractions on submicrometer pillars.},
  author={Saba Ghassemi and Giovanni Meacci and Shuaimin Liu and Alexander A Gondarenko and Anurag Mathur and Pere Roca-Cusachs and Michael P Sheetz and James Hone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 14},
Cell growth and differentiation are critically dependent upon matrix rigidity, yet many aspects of the cellular rigidity-sensing mechanism are not understood. Here, we analyze matrix forces after initial cell-matrix contact, when early rigidity-sensing events occur, using a series of elastomeric pillar arrays with dimensions extending to the submicron scale (2, 1, and 0.5 μm in diameter covering a range of stiffnesses). We observe that the cellular response is fundamentally different on micron… CONTINUE READING
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