Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress.

@article{Boada2000CellsOF,
  title={Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress.},
  author={Jordi Boada and Teresa Sandoval Roig and X Vel{\'a}zquez P{\'e}rez and Antonio Bl{\'a}zquez G{\'a}mez and Ramon Bartrons and Marta Cascante and J Rafael Berm{\'u}dez},
  journal={FEBS letters},
  year={2000},
  volume={480 2-3},
  pages={
          261-4
        }
}
Changes in the content of fructose-2,6-bisphosphate, a modulator of glycolytic flux, also affect other metabolic fluxes such as the non-oxidative pentose phosphate pathway. Since this is the main source of precursors for biosynthesis in proliferating cells, PFK-2/FBPase-2 has been proposed as a potential target for neoplastic treatments. Here we provide evidence that cells with a low content of fructose-2,6-bisphosphate have a lower energy status than controls, but they are also less sensitive… CONTINUE READING
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