Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells.

@article{Alon2008CellsOT,
  title={Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells.},
  author={Ronen Alon and Klaus Ley},
  journal={Current opinion in cell biology},
  year={2008},
  volume={20 5},
  pages={
          525-32
        }
}
  • Ronen Alon, Klaus Ley
  • Published 2008
  • Biology, Medicine
  • Current opinion in cell biology
  • The arrest of rolling leukocytes on various target vascular beds is mediated by specialized leukocyte integrins and their endothelial immunoglobulin superfamily (IgSF) ligands. These integrins are kept in largely inactive states and undergo in situ activation upon leukocyte-endothelial contact by both biochemical and mechanical signals from flow-derived shear forces. In vivo and in vitro studies suggest that leukocyte integrin activation involves conformational alterations through inside-out… CONTINUE READING

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