Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells.

Abstract

The arrest of rolling leukocytes on various target vascular beds is mediated by specialized leukocyte integrins and their endothelial immunoglobulin superfamily (IgSF) ligands. These integrins are kept in largely inactive states and undergo in situ activation upon leukocyte-endothelial contact by both biochemical and mechanical signals from flow-derived… (More)
DOI: 10.1016/j.ceb.2008.04.003

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