Cells keep a memory of their tissue origin during axolotl limb regeneration

@article{Kragl2009CellsKA,
  title={Cells keep a memory of their tissue origin during axolotl limb regeneration},
  author={M. Kragl and D. Knapp and E. Nacu and S. Khattak and M. Maden and H. Epperlein and E. Tanaka},
  journal={Nature},
  year={2009},
  volume={460},
  pages={60-65}
}
During limb regeneration adult tissue is converted into a zone of undifferentiated progenitors called the blastema that reforms the diverse tissues of the limb. Previous experiments have led to wide acceptance that limb tissues dedifferentiate to form pluripotent cells. Here we have reexamined this question using an integrated GFP transgene to track the major limb tissues during limb regeneration in the salamander Ambystoma mexicanum (the axolotl). Surprisingly, we find that each tissue… Expand
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