Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs.

@article{Kalamvoki2014CellsIW,
  title={Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs.},
  author={Maria Kalamvoki and Te Du and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 46},
  pages={
          E4991-6
        }
}
  • Maria Kalamvoki, Te Du, Bernard Roizman
  • Published in
    Proceedings of the National…
    2014
  • Biology, Medicine
  • STING (stimulator of IFN genes) activates the IFN-dependent innate immune response to infection on sensing the presence of DNA in cytosol. The quantity of STING accumulating in cultured cells varies; it is relatively high in some cell lines [e.g., HEp-2, human embryonic lung fibroblasts (HEL), and HeLa] and low in others (e.g., Vero cells). In a preceding publication we reported that STING was stable in four cell lines infected with herpes simplex virus 1 and that it was actively stabilized in… CONTINUE READING

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    Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.