Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs.

@article{Kalamvoki2014CellsIW,
  title={Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs.},
  author={Maria Kalamvoki and Te Du and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 46},
  pages={E4991-6}
}
STING (stimulator of IFN genes) activates the IFN-dependent innate immune response to infection on sensing the presence of DNA in cytosol. The quantity of STING accumulating in cultured cells varies; it is relatively high in some cell lines [e.g., HEp-2, human embryonic lung fibroblasts (HEL), and HeLa] and low in others (e.g., Vero cells). In a preceding publication we reported that STING was stable in four cell lines infected with herpes simplex virus 1 and that it was actively stabilized in… CONTINUE READING
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Herpes simplex viruses

  • B Roizman, DM Knipe, RJ Whitley
  • Fields’ Virology, eds Knipe DM, et al. (Wolters…
  • 2013
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