• Corpus ID: 166227858

Cells exploit a phase transition to establish interconnections in fibrous extracellular matrices

@article{Grekas2019CellsEA,
  title={Cells exploit a phase transition to establish interconnections in fibrous extracellular matrices},
  author={G. Grekas and Maria Proestaki and Phoebus Rosakis and Jacob Notbohm and Charalambos Makridakis and Guruswami Ravichandran},
  journal={arXiv: Biological Physics},
  year={2019}
}
By exerting mechanical forces, biological cells generate striking spatial patterns of localised deformation in the surrounding collagen network. Tethers-paths of high densification and fiber alignment-form between cells, and radial hair-like bands emanate from cell clusters. While tethers facilitate cell communication, the mechanism for their formation is unclear. Here we combine modelling, simulation and experiment, and explore unexpected similarities with martensitic microstructures in shape… 

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