Cells carrying nonlymphoma-associated bcl-2/IgH rearrangements (NLABR) are phenotypically related to follicular lymphoma and can establish as long-term persisting clonal populations.

@article{Ladetto2006CellsCN,
  title={Cells carrying nonlymphoma-associated bcl-2/IgH rearrangements (NLABR) are phenotypically related to follicular lymphoma and can establish as long-term persisting clonal populations.},
  author={Marco Ladetto and B{\'a}rbara Mantoan and Federica De Marco and Daniela Drandi and Chiara Aguzzi and Monica Astolfi and Sonia Vallet and Irene Ricca and Maria Dell' Aquila and Gloria Pagliano and Luigia Monitillo and Berardino Pollio and Loredana Santo and Carmen Cristiano and Alberto Rocci and Roberto Francese and Chiara Lobetti Bodoni and Alessandra Borchiellini and Piercarla Schinco and Mario Boccadoro and Corrado Tarella},
  journal={Experimental hematology},
  year={2006},
  volume={34 12},
  pages={1680-6}
}
OBJECTIVE Nonlymphoma-associated bcl-2/IgH rearrangements (NLABRs) are frequently amplified by PCR in blood of lymphoma-free subjects (LFS), but the temporal kinetics and phenotypic nature of NLABR-positive cells are unknown. To address these issues we prospectively monitored a panel of NLABR-positive LFS. METHODS LFS have been studied by nested PCR, real-time PCR, and DNA sequencing. Cell selection studies were also performed to define the nature of NLABR-bearing clones. RESULTS Of 125… CONTINUE READING