Cells and prions: a license to replicate.

  title={Cells and prions: a license to replicate.},
  author={Mario Nuvolone and Adriano Aguzzi and Mathias Heikenwalder},
  journal={FEBS letters},
  volume={583 16},
Prion diseases are neurodegenerative, infectious disorders characterized by the aggregation of a misfolded isoform of the cellular prion protein (PrP(C)). The infectious agent - termed prion - is mainly composed of misfolded PrP(Sc). In addition to the central nervous system prions can colonize secondary lymphoid organs and inflammatory foci. Follicular dendritic cells are important extraneural sites of prion replication. However, recent data point to a broader range of cell types that can… CONTINUE READING

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