Cells Regardless of the of Thymidylate Kinase and Doxorubicin in Colon Cancer Synthetic Lethality by Lentiviral Short Hairpin RNA Silencing


Intracellular supply of dTTP is a highly regulated process and has been a key target for chemotherapeutic drug development. Thymidylate kinase (TMPK) is the key enzyme for dTTP formation in both de novo and salvage pathways. In this study, we used lentiviral-based small hairpin RNA to silence TMPK expression in p53(+/+) and p53( / ) HCT-116 colon cancer… (More)


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