Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations

@article{Shapiro2003CelleratorEA,
  title={Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations},
  author={Bruce E. Shapiro and Andre Levchenko and Elliot M. Meyerowitz and Barbara J. Wold and Eric Mjolsness},
  journal={Bioinformatics},
  year={2003},
  volume={19 5},
  pages={
          677-8
        }
}
Cellerator describes single and multi-cellular signal transduction networks (STN) with a compact, optionally palette-driven, arrow-based notation to represent biochemical reactions and transcriptional activation. Multi-compartment systems are represented as graphs with STNs embedded in each node. Interactions include mass-action, enzymatic, allosteric and connectionist models. Reactions are translated into differential equations and can be solved numerically to generate predictive time courses… CONTINUE READING

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