CellNet: Network Biology Applied to Stem Cell Engineering

@article{Cahan2014CellNetNB,
  title={CellNet: Network Biology Applied to Stem Cell Engineering},
  author={Patrick Cahan and Hu Li and Samantha A. Morris and Edroaldo Lummertz da Rocha and George Q. Daley and James J. Collins},
  journal={Cell},
  year={2014},
  volume={158},
  pages={903-915}
}
Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct conversions between differentiated cell lineages represent powerful approaches to engineer cells for research and regenerative medicine. We have developed CellNet, a network biology platform that more accurately assesses the fidelity of cellular engineering than existing methodologies and generates hypotheses for improving cell derivations. Analyzing expression data from 56 published reports, we found… CONTINUE READING

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