Cell walls from avirulent variants of Histoplasma capsulatum lack alpha-(1,3)-glucan.

  title={Cell walls from avirulent variants of Histoplasma capsulatum lack alpha-(1,3)-glucan.},
  author={Kurt R. Klimpel and William E Goldman},
  journal={Infection and immunity},
  volume={56 11},
Cell wall composition of isogenic virulent-avirulent strain pairs of Histoplasma capsulatum varied markedly with respect to alpha-(1,3)-glucan content. When yeast cell walls were fractionated by standard techniques, the avirulent strains contained up to 1,000-fold less alpha-(1,3)-glucan than did their virulent parents. No alpha-(1,3)-glucan could be detected on the surface of the avirulent strain yeast cells if we used a mouse monoclonal antibody that recognized this polymer. A similar… CONTINUE READING

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