Cell wall integrity modulates RHO1 activity via the exchange factor ROM2

  title={Cell wall integrity modulates RHO1 activity via the exchange factor ROM2},
  author={M. Bickle and P. Delley and A. Schmidt and M. Hall},
  journal={The EMBO Journal},
  • M. Bickle, P. Delley, +1 author M. Hall
  • Published 1998
  • Biology, Medicine
  • The EMBO Journal
  • The essential phosphatidylinositol kinase homologue TOR2 of Saccharomyces cerevisiae controls the actin cytoskeleton by activating a GTPase switch consisting of RHO1 (GTPase), ROM2 (GEF) and SAC7 (GAP). We have identified two mutations, rot1‐1 and rot2‐1, that suppress the loss of TOR2 and are synthetic‐lethal. The wild‐type ROT1 and ROT2 genes and a multicopy suppressor, BIG1, were isolated by their ability to rescue the rot1‐1 rot2‐1 double mutant. ROT2 encodes glucosidase II, and ROT1 and… CONTINUE READING
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