Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post‐transcriptional regulator Ccr4‐Pop2

@article{Dagley2011CellWI,
  title={Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post‐transcriptional regulator Ccr4‐Pop2},
  author={Michael J. Dagley and Ian Edward Gentle and Traude H. Beilharz and Filomena Angela Pettolino and Julianne Teresa Djordjevic and Tricia L Lo and Nathalie Uwamahoro and Thusitha W T Rupasinghe and Dedreja L Tull and Malcolm J. McConville and C{\'e}cile Beaurepaire and Andr{\'e} Nantel and Trevor Lithgow and Aaron P. Mitchell and Ana Traven},
  journal={Molecular Microbiology},
  year={2011},
  volume={79}
}
The cell wall is essential for viability of fungi and is an effective drug target in pathogens such as Candida albicans. The contribution of post‐transcriptional gene regulators to cell wall integrity in C. albicans is unknown. We show that the C. albicans Ccr4‐Pop2 mRNA deadenylase, a regulator of mRNA stability and translation, is required for cell wall integrity. The ccr4/pop2 mutants display reduced wall β‐glucans and sensitivity to the echinocandin caspofungin. Moreover, the deadenylase… 
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