Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2.

@article{Dagley2011CellWI,
  title={Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2.},
  author={Michael J. Dagley and Ian E Gentle and Traude H Beilharz and Filomena Angela Pettolino and Julianne Teresa Djordjevic and Tricia L. Lo and Nathalie Uwamahoro and Thusitha Rupasinghe and Dedreja L Tull and Malcolm McConville and C{\'e}cile Beaurepaire and Andr{\'e} M. Nantel and Trevor Lithgow and Aaron P. Mitchell and Ana Traven},
  journal={Molecular microbiology},
  year={2011},
  volume={79 4},
  pages={968-89}
}
The cell wall is essential for viability of fungi and is an effective drug target in pathogens such as Candida albicans. The contribution of post-transcriptional gene regulators to cell wall integrity in C. albicans is unknown. We show that the C. albicans Ccr4-Pop2 mRNA deadenylase, a regulator of mRNA stability and translation, is required for cell wall integrity. The ccr4/pop2 mutants display reduced wall β-glucans and sensitivity to the echinocandin caspofungin. Moreover, the deadenylase… CONTINUE READING