Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans.

@article{Gerik2005CellWI,
  title={Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans.},
  author={Kimberly J. Gerik and Maureen J. Donlin and Carlos E. Soto and Annette M Banks and Isaac R. Banks and Marybeth A. Maligie and Claude P. Selitrennikoff and Jennifer K. Lodge},
  journal={Molecular microbiology},
  year={2005},
  volume={58 2},
  pages={393-408}
}
Cell wall biogenesis and integrity are crucial for fungal growth, pathogenesis and survival, and are attractive targets for antifungal therapy. In this study, we identify, delete and analyse mutant strains for 10 genes involved in the PKC1 signal transduction pathway and its regulation in Cryptococcus neoformans. The kinases Bck1 and Mkk2 are critical for maintaining integrity, and deletion of each of these causes severe phenotypes different from each other. In stark contrast to results seen in… CONTINUE READING