Cell volume regulation modulates NLRP3 inflammasome activation.

@article{Compan2012CellVR,
  title={Cell volume regulation modulates NLRP3 inflammasome activation.},
  author={Vincent Compan and Alberto Baroja-Mazo and Gloria L{\'o}pez-Castej{\'o}n and Ana I. G{\'o}mez and Carlos Manuel Mart{\'i}nez and Diego Angosto and Mar{\'i}a T Montero and Antonio S{\'a}nchez Herranz and Eulalia Baz{\'a}n and Diana Reimers and Victoriano Mulero and Pablo Pelegr{\'i}n},
  journal={Immunity},
  year={2012},
  volume={37 3},
  pages={487-500}
}
Cell volume regulation is a primitive response to alterations in environmental osmolarity. The NLRP3 inflammasome is a multiprotein complex that senses pathogen- and danger-associated signals. Here, we report that, from fish to mammals, the basic mechanisms of cell swelling and regulatory volume decrease (RVD) are sensed via the NLRP3 inflammasome. We found that a decrease in extracellular osmolarity induced a K(+)-dependent conformational change of the preassembled NLRP3-inactive inflammasome… CONTINUE READING
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