Cell volume regulation in intestinal epithelial cells: Role of Cl- channels

@inproceedings{Manabe2004CellVR,
  title={Cell volume regulation in intestinal epithelial cells: Role of Cl- channels},
  author={Ken-ichi Manabe and Yasunobu Okada},
  year={2004}
}
Cell volume regulation under osmotic stress is one of the important cell functions to maintain cell homeostasis. Absorptive intestinal epithelial cells are obliged to swell in association with active absorption of nutrients, whereas secretory cells in the intestinal crypt exhibit shrinkage due to Na+ and H2O secretion driven by active Cl- secretion. After osmotic swelling and shrinkage, intestinal epithelial cells undergo a regulatory volume decrease (RVD) or a regulatory volume increase (RVI… CONTINUE READING