Cell volume regulation in human neutrophils: 2-(aminomethyl)phenols as Cl- channel inhibitors.

@article{Simchowitz1993CellVR,
  title={Cell volume regulation in human neutrophils: 2-(aminomethyl)phenols as Cl- channel inhibitors.},
  author={Louis Simchowitz and Jamie A Textor and Edward J. Cragoe},
  journal={The American journal of physiology},
  year={1993},
  volume={265 1 Pt 1},
  pages={C143-55}
}
When subjected to hypotonic stress, human peripheral neutrophils initially swell due to rapid water entry and thereafter recover toward the normal cell size (approximately 330 microns 3). Neutrophils do not behave as perfect osmometers: when resuspended in half-isotonic medium (150 mosM), they swell by only approximately 40% rather than doubling in size as predicted for ideal behavior. As with lymphocytes, restoration to the normal cell size involves the net loss of K+ and Cl- from the cytosol… CONTINUE READING

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