Cell volume changes modulate cholecystokinin- and carbachol-stimulated amylase release in isolated rat pancreatic acini.


BACKGROUND & AIMS Changes in cell volume have been recently identified as modulators of cell function and gene expression. This study evaluated the regulation of exocrine secretion by pancreatic acini on the basis of changes in cell hydration. METHODS Acini were exposed to hypotonicity or hypertonicity. The effects of corresponding changes in cell volume… (More)


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