Cell volume, K transport, and cell density in human erythrocytes.

  title={Cell volume, K transport, and cell density in human erythrocytes.},
  author={Carlo Brugnara and Daniel C. Tosteson},
  journal={The American journal of physiology},
  volume={252 3 Pt 1},
We report here studies on the regulation of cell volume and K transport in human erythrocytes separated according to density. When cell volume was increased (isosmotic swelling, nystatin technique), erythrocytes of the least dense but not of the densest fraction shrunk back toward their original volume. This process was due to a ouabain (0.1 mM) and bumetanide (0.01 mM) (OB)-resistant K loss. OB-resistant K+ efflux from the least dense fraction was stimulated by hypotonic swelling and had a… CONTINUE READING