Cell-type-specific roles for COX-2 in UVB-induced skin cancer.

  title={Cell-type-specific roles for COX-2 in UVB-induced skin cancer.},
  author={J. -F. Jiao and Carol D Mikulec and Tomo-o Ishikawa and Clara E. Magyar and Darren S. Dumlao and Edward A. Dennis and Susan M. Fischer and Harvey R. Herschman},
  volume={35 6},
In human tumors, and in mouse models, cyclooxygenase-2 (COX-2) levels are frequently correlated with tumor development/burden. In addition to intrinsic tumor cell expression, COX-2 is often present in fibroblasts, myofibroblasts and endothelial cells of the tumor microenvironment, and in infiltrating immune cells. Intrinsic cancer cell COX-2 expression is… CONTINUE READING