Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76.

@article{Merrill2006CelltypespecificRO,
  title={Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76.},
  author={Melinda K. Merrill and Elena Dobrikova and Matthias Gromeier},
  journal={Journal of virology},
  year={2006},
  volume={80 7},
  pages={3147-56}
}
Translation of picornavirus plus-strand RNA genomes occurs via internal ribosomal entry at highly structured 5' untranslated regions. In addition to canonical translation factors, translation rate is likely influenced by supplementary host and viral trans-acting factors. We previously reported that insertion of a heterologous human rhinovirus type 2 internal ribosomal entry site (IRES) into the poliovirus (PV) genome, generating the chimeric virus PV-RIPO, selectively abrogates viral… CONTINUE READING
34 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…