Cell-type-specific regulation of the two foamy virus promoters.

  title={Cell-type-specific regulation of the two foamy virus promoters.},
  author={Christopher D. Meiering and Claudia A. Rubio and Cynthia May and Maxine L. Linial},
  journal={Journal of virology},
  volume={75 14},
The foamy virus (FV) genome contains two promoters, the canonical long terminal repeat (LTR) promoter, containing three consensus AP-1 binding sites, and an internal promoter (IP) within the env gene. We investigated the regulation of the two promoters in lytic and persistent infections and found that in the presence of a constitutive source of the viral transactivator protein Tas, transactivation of the LTR promoter and that of the IP differ. In lytic infections, both the LTR promoter and the… CONTINUE READING


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