Cell type-specific regulation of beta2-adrenoceptor mRNA by agonists.

@article{Danner1997CellTR,
  title={Cell type-specific regulation of beta2-adrenoceptor mRNA by agonists.},
  author={Sandra Danner and Martin J. Lohse},
  journal={European journal of pharmacology},
  year={1997},
  volume={331 1},
  pages={73-8}
}
Prolonged agonist stimulation of beta2-adrenoceptors results in receptor down-regulation which is often paralleled by a reduction of the corresponding mRNA. In this study, we investigated the agonist-dependent regulation of beta2-adrenoceptor mRNA in DDT1-MF2 smooth muscle cells and C6 glioma cells. In DDT1-MF2 cells the half-life of the mRNA was 12 h in monolayer compared to 2 h in suspension cultures. Under both conditions, the agonist isoproterenol reduced this half-life by a factor of 2. In… CONTINUE READING