Cell type-specific regulation of RhoA activity during cytokinesis.

  title={Cell type-specific regulation of RhoA activity during cytokinesis.},
  author={Hisayoshi Yoshizaki and Yusuke Ohba and Maria-Carla Parrini and Natalya G. Dulyaninova and Anne R. Bresnick and Naoki Mochizuki and Michiyuki Matsuda},
  journal={The Journal of biological chemistry},
  volume={279 43},
Rho family GTPases play pivotal roles in cytokinesis. By using probes based on the principle of fluorescence resonance energy transfer (FRET), we have shown that in HeLa cells RhoA activity increases with the progression of cytokinesis. Here we show that in Rat1A cells RhoA activity remained suppressed during most of the cytokinesis. Consistent with this observation, the expression of C3 toxin inhibited cytokinesis in HeLa cells but not in Rat1A cells. Furthermore, the expression of a dominant… CONTINUE READING


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