Cell-type-specific opening of the retinal ganglion cell mitochondrial permeability transition pore.

@article{Vrabec2003CelltypespecificOO,
  title={Cell-type-specific opening of the retinal ganglion cell mitochondrial permeability transition pore.},
  author={Joshua P Vrabec and Christopher J. Lieven and Leonard A Levin},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 6},
  pages={2774-82}
}
PURPOSE To study the role of the mitochondrial permeability transition pore (PTP) in apoptosis of axotomized retinal ganglion cells (RGCs) in vitro. METHODS Primary rat retinal cultures containing DiI-labeled RGCs were treated with pharmacological agents that modulate the PTP. Ratiometric imaging of the mitochondrial membrane potential (DeltaPsi(m)) were conducted on similarly treated cultures, with the dual-emission probe JC-1, and the correlation with the results of the viability… CONTINUE READING
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