Cell type-specific occurrence of caveolin-1alpha and -1beta in the lung caused by expression of distinct mRNAs.

@article{Kogo2004CellTO,
  title={Cell type-specific occurrence of caveolin-1alpha and -1beta in the lung caused by expression of distinct mRNAs.},
  author={Hiroshi Kogo and Toshisada Aiba and Toyoshi Fujimoto},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 24},
  pages={25574-81}
}
Two isoforms of caveolin-1, alpha and beta, had been thought to be generated by alternative translation initiation of an mRNA (FL mRNA), but we showed previously that a variant mRNA (5'V mRNA) encodes the beta isoform specifically. In the present study, we demonstrated strong correlation between the expression of the caveolin-1 protein isoforms and mRNA variants in culture cells and the developing mouse lung. The alpha isoform protein and FL mRNA were expressed constantly during the lung… CONTINUE READING

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