Cell type-specific involvement of RIG-I in antiviral response.

  title={Cell type-specific involvement of RIG-I in antiviral response.},
  author={Hiroki Kato and Shintaro Sato and M. Yoneyama and Masahiro Yamamoto and Satoshi Uematsu and Kosuke Matsui and Tohru Tsujimura and Kiyoshi Takeda and Takashi Fujita and Osamu Takeuchi and Shizuo Akira},
  volume={23 1},
Toll-like receptors (TLRs) play an important role in antiviral response by recognizing viral components. Recently, a RNA helicase, RIG-I, was also suggested to recognize viral double-stranded RNA. However, how these molecules contribute to viral recognition in vivo is poorly understood. We show by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). RIG-I induces type I IFNs by… CONTINUE READING
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