Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.

  title={Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.},
  author={Lei Wang and Yi Zheng},
  journal={Trends in cell biology},
  volume={17 2},
Mammalian Rho family GTPases are intracellular signal transducers known to regulate multiple signaling pathways involved in actin organization and cell proliferation. However, previous knowledge of their cellular functions came mostly from studies using a dominant-negative or constitutively active mutant expression approach in various clonal cell lines. Such an approach has increasingly been recognized to impose experimental limitations related to specificity, dosage and/or clonal variation… CONTINUE READING


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