Cell type-specific expression of nuclear lamina proteins during development of Xenopus laevis

  title={Cell type-specific expression of nuclear lamina proteins during development of Xenopus laevis},
  author={R. Cabello Benavente and Georg Krohne and Werner Franke},
The cell type-specific expression of the major nuclear lamina polypeptides ("lamins") during development of Xenopus was studied using two monoclonal antibodies (L(0)46F7: specific for LIII, the single lamin of oocytes; PKB8: specific for LI and LII of some somatic cells). In the oocyte, LIII localizes in the nuclear polymer, but upon nuclear envelope breakdown it is solubilized to a form sedimenting at 9 S. In early embryos, LIII contributes to nuclear lamina formation until its depletion… CONTINUE READING

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