Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI

@article{Urban2018CelltypeSE,
  title={Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI},
  author={Mark William Urban and Biswarup Ghosh and Laura R. Strojny and Cole G. Block and Angelo C Lepore},
  journal={Experimental Neurology},
  year={2018},
  volume={303},
  pages={108-119}
}
Damage to respiratory neural circuitry and consequent loss of diaphragm function is a major cause of morbidity and mortality in individuals suffering from traumatic cervical spinal cord injury (SCI). Repair of CNS axons after SCI remains a therapeutic challenge, despite current efforts. SCI disrupts inspiratory signals originating in the rostral ventral respiratory group (rVRG) of the medulla from their phrenic motor neuron (PhMN) targets, resulting in loss of diaphragm function. Using a rat… CONTINUE READING
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