Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper (GILZ) gene by estrogen

@article{Tynan2004CellTB,
  title={Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper (GILZ) gene by estrogen},
  author={Sharon H. Tynan and Scott G. Lundeen and George F. Allan},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2004},
  volume={91},
  pages={225-239}
}
Estrogen has numerous beneficial physiological actions; however, by acting as a mitogen, it plays a significant role in the induction and maintenance of breast cancer. Although the positive effects of estrogen on gene expression are well described, negative gene regulation is not. Using microarray analysis, we identified 27 genes that were up-regulated and 20 that were down-regulated by estrogen in MCF-7 human breast cancer cells. One gene encoding GILZ (glucocorticoid-induced leucine zipper… CONTINUE READING

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