Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3.

@article{Xu1999CellTA,
  title={Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3.},
  author={Fenghao Xu and Huiping Li and Taocong Jin},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 48},
  pages={34310-6}
}
The caudal-related homeobox gene Cdx-2/3 is a critical "master" control gene in embryogenesis. Mice heterozygous for a null mutation in Cdx-2/3 exhibit multiple malfunctions including tail abnormalities, stunted growth, a homeotic shift in vertebrae, and the development of multiple intestinal adenomatous polyps, indicating that Cdx-2/3 is haplo-insufficient. In vitro studies have identified more than a half-dozen downstream target genes expressed in pancreatic and intestinal cells for this… CONTINUE READING

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