Cell type-specific association of hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein accumulation and radiobiologic tumor hypoxia.

Abstract

PURPOSE The transcription factor subunit hypoxia-inducible factor-1 alpha (HIF-1 alpha) is currently discussed as a potential endogenous marker of tumor hypoxia to select patients for modified treatment. Despite an association of immunohistochemical HIF-1 alpha overexpression and poor prognosis after radiotherapy in many tumor entities, the reported pattern… (More)

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@article{Vordermark2004CellTA, title={Cell type-specific association of hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein accumulation and radiobiologic tumor hypoxia.}, author={Dirk Vordermark and Astrid Katzer and Kurt Baier and Peter Kraft and Michael Flentje}, journal={International journal of radiation oncology, biology, physics}, year={2004}, volume={58 4}, pages={1242-50} }