Cell type-specific STAT3 activation by gp130-related cytokines in the peripheral nerves.

@article{Wang2009CellTS,
  title={Cell type-specific STAT3 activation by gp130-related cytokines in the peripheral nerves.},
  author={Lih Shinn Wang and Hyun Kyoung Lee and In Seo and Yoon Kyung Shin and Kyu Yeol Lee and Hwan Tae Park},
  journal={Neuroreport},
  year={2009},
  volume={20 7},
  pages={663-8}
}
Nerve injury-induced activation of signal transducer and activator of transcription 3 (STAT3) in sensory neurons and Schwann cells has been implicated in peripheral nerve regeneration. In this study, we investigated the role of gp130-related cytokines including interleukin-6 (IL-6), ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF) in STAT3 activation in dorsal root ganglion neurons, Schwann cells, and endoneurial fibroblasts. We found that IL-6, but not CNTF or LIF… CONTINUE READING